On May 24, 2016, at 10 a.m. the "Karlsruhe" was tasked to a distressed migrant boat 90 kilometers NW of Tripoli. On scene the fregate took aboad 289 migrants from two rubber boats, aming them 95 women and four children. Also two women and two children were transferred aboard from the British HMS "Enterprise" for medical treatment. The boats were sunk as navigational hazards. With on the whole 191 men, 97 women and six children aboard the ship headed to Brindisi, ETA May 26, where they were to be handed over to the Italian authorities.